![]() ![]() ![]() These recommendations and guidelines may include obligatory measures and have high normative value but are not specifically targeted at cancer patients. Several institutions and public authorities have issued comprehensive guidelines on CRIs such as the German Commission for Control and Prevention of Infections (KRINKO). Importantly, up to 70% of all CRIs may be preventable with current evidence-based strategies. The associated mortality ranges from 12 to 40% depending on several factors, including patient comorbidities, CVC type, and microorganism causing the infection. The frequency of resulting central line–associated bloodstream infections (CLABSIs) in cancer patients is estimated at 0.5– CVC-days. According to current estimates, more than 5 million CVCs are inserted in the USA annually and similar rates have been reported for European countries. However, cancer patients are at particular risk of infections including CVC-related infections (CRIs) due to disease- and treatment-related immunosuppression. This guideline supports clinicians and researchers alike in the evidence-based decision-making in the management of CRIs in cancer patients.Ĭancer patients frequently require central venous catheters (CVCs) for cancer treatment, blood transfusion, and parenteral nutrition. In the presented guideline, we summarize recommendations on definition, diagnosis, management, and prevention of CRIs in cancer patients including the grading of strength of recommendations and the respective levels of evidence. After conducting systematic literature searches on PubMed, Medline, and Cochrane databases, video- and meeting-based consensus discussions were held. We therefore summoned a panel of experts by the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) and updated our previous guideline on CRIs in cancer patients. Moreover, CRIs prolong hospitalization, cause an excess in resource utilization and treatment cost, often delay anti-cancer treatment, and are associated with a significant increase in mortality in cancer patients. Cancer patients frequently require central venous catheters for therapy and parenteral nutrition and are at high risk of central venous catheter–related infections (CRIs). ![]()
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